The prognostic significance of clinicopathological features and apoptosis inhibi- tor proteins in pancreas ductal adenocarcinoma
Journal | Volume 77 - 2014 |
Issue | Fasc.2 - Original articles |
Author(s) | Asuman Argon, Deniz Nart, Nevin Oruç, Ahmet çoker, ömer özütemiz |
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(1) Izmir Bozyaka Training and Research Hospital, Departments of Pathology, Izmir, Turkey ; (2) Departments of Pathology, (3) Departments of Gastroenterology, (4) Departments of General Surgery, Ege University School of Medicine, Izmir, Turkey. |
Introduction: Pancreas ductal adenocarcinoma (PDAC) is among tumors with unfavorable prognosis. The aim of this study was to determine potential prognostic factors in PDAC. Materials and methods : We retrospectively evaluated a total of 117 cases according to clinicopathological parameters and survivin and livin expression. We investigated the relationship between these parameters and their prognostic significance. Results : In univariate analysis, lymph node metastasis, surgical margin positivity, tumor size over 4 cm and survivin expression were associated with poorer survival but livin expression was not correlated with survival-time. In multivariate analysis, only lymph node metastasis was independent factor predicting a poorer out- come. Conclusions : In present study, the lymph node metastasis was the strongest predictor of survival. Our finding suggest that sur- vivin could be a target for the treatment of advanced stage resect- able PDAC. Our results need to be supported by studies on larger series with advanced techniques. (Acta gastroenterol. belg., 2014, 77, 229-234). |
© Acta Gastro-Enterologica Belgica. PMID 25090821 |